Research Summary

Dr. Xiao-Ying Hua My major research interests include (1) investigation of role of selective protein kinases including protein kinase C (PKCα isoform) and mitogen-activated protein kinases (P38α, P38β) in spinal pain transmission by using intrathecal antisense approach; (2) study of activation and regulation of these protein kinases at spinal level during tissue injury/inflammation and development of morphine tolerance; and (3) participation of non-neuronal cells, such as microglia and astrocytes, in spinal hyperexcitability.


Selected Publications

Hua, X.-Y., A. Moore, S. Malkmus, S.F. Murray, N. Dean, T.L. Yaksh & M. Butler. Inhibition of spinal protein kinase C alpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance. Neuroscience, 113:99-107, 2002.

Svensson C.I., X.-Y. Hua, A.A. Protter, H.C. Powell & T.L. Yaksh. Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE2 release and thermal hyperalgesia. Neuroreport 14:1153-1157, 2003.

Butler, M., C.S. Hayes, A. Chappel, S.F. Murray, T.L. Yaksh & X-Y Hua. Spinal distribution and metabolism of 2'-O-(2-Methoxyethyl)-modified oligonucleotides after intrathecal administration in rats. Neuroscience 131: 705-714, 2005.

Svensson C.I., B. Fitzmmons, S. Azizi, H.C. Powell, X.-Y. Hua, & T.L. Yaksh. Spinal p38β isoform mediates tissue injury-induced hyperalgesia and spinal sensitization. J. Neurochem. 92:1508-1520, 2005.

Svensson, C.I., X.-Y. Hua, H.C. Powell, E.A. J. Lai, F. Porreca & T.L. Yaksh. Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase. Neuropeptides, 39: 485-494, 2005.

Hua, X.-Y., C.I. Svensson, T. Matsui, B. Fitzmmons, T.L. Yaksh & M. Webb. Intrathecal minocycline attenuates peripheral inflammation-induced hyperalgesia by inhibiting p38 MAPK in spinal microglia. Eur J Neurosci, 22: 2431-2440, 2005.

Background

  • M.D. from Capital University of Medical Science, Beijing, China (1977)
  • Ph.D. from Karolinska Institute, Stockholm, Sweden (1986)
  • Research Scientist, Anesthesiology, University California San Diego (1989- present)